There is evidence of a substantial ...

The remaining 40% is a socio-cultural influences and other life events [24]. Predisposing to the development of dependence genes remain to be identified. In this regard, candidate genes are alleles of DRD2 (dopamine receptor gene). As gene-protector (protection factor) is set to the gene responsible for a higher level of the first product of the splitting of alcohol - acetaldehyde. Relevant enzymes are variants of alcohol dehydrogenase and aldehyde dehydrogenase. Protective genetic variants of enzymes are found only among the peoples of Asia, Japanese, Chinese, Koreans. In European populations, these genes protectors are not detected. The biological factors are also at risk of low amplitude wave RZOO evoked potentials, and low levels of serotonin in cerebrospinal fluid. Individual risk factors Risk factors, partly due to genetic influence, may include some individual characteristics that increase the likelihood of alcohol use, abuse and the development of dependence. This increased impulsivity, the desire to seek novelty, a syndrome of childhood hyperactivity, behavioral disorders in childhood (eksternalizo towels behavior), this complex is called "neural and behavioral disinhibition [24]. Low level of response to alcohol (the ability to not get drunk at the use of relatively high doses of alcohol) was found in almost half of adult children of alcoholics fathers. According to the 15-year longitudinal observation and repeated laboratory tests of the sons of alcoholics fathers, low response to alcohol in a 3-4 times increased risk of alcohol abuse or dependence on him in catamnesis [23]. Established that lack of control of their impulses from the sons of alcoholics Fathers manifested early, as early as 3 to 5 years of age and in later life is a mediator between parental alcoholism and antisotsialnm behavior [16]. Antisocial personality (according to the classification DSM-IV) can also be attributed to individual risk factors. There is evidence of a significant contribution of genetic factors in the formation of this personality disorder. Analyzes data on 324 monozygotic and 335 dizygotic pairs of twins found that personality traits are considered components of antisocial personality (grandiosity, attention seeking, incentives and innovation, the rejection of social norms and antisocial behavior in their youth) are influenced by genetic factors common to those, determining alcohol [II]. A linear relationship: the more severe manifestations of antisocial personality, the higher the frequency of alcohol dependence. Drug use is also associated with the severity of the manifestations of antisocial personality among both men and women [b]. Parental alcoholism is often co-exists with the antisocial behavior of both the parents and their children. Risk factors include behavior that leads to a clash with police. In the group with the presence of this factor is 18.8% of teens have used illegal drugs compared with 1.6% of those who had no difficulties with the police [27]. S.