O in small doses, also reduced the ...

It should be noted, however, that in all these studies dealt with on an outpatient treatment of patients with shallow depressions neurotic level. On expression of anxiolytic action of F equated with diazepam [36]. It was noted, and activates the "energizing" effect of the drug [40]. Thus, having a mild antidepressant, protivotrevozhnym and activating effect F can be used for the treatment of superficial comorbid depression, including the presence of apathy and / or anxiety in patients with alcoholism. A possible explanation for the presence of an antidepressant effect in F is the profile of the drug effects on receptors where the affinity for D2 dopamine receptors, so typical of classical antipsychotics, combined with the blockade of D1 dopamine receptors and effects on serotonin 5-HT2 receptors, which makes F with atypical antipsychotics [43 ]. It should be noted that the treatment of shallow depressions F in small doses even has a well-known advantages over classical antidepressants. Firstly, it surpasses them by the speed of antidepressant action, which manifests itself in his already 2-3 days after start of [39]. Second, the F in low doses practically does not affect psychomotor performance [42]. Thirdly, the flupentiksola less severe side effects [36] and, finally, it is safer than TCAs in overdose [35]. Of particular interest are studies of the impact of various psychopharmacological agents on suicidal behavior and the repetition of self-harm. For example, a recent study in Britain found that flupentiksol depot significantly reduces the risk of repeated severe self-harm in individuals gravitate to such a pattern of behavior [45]. O in small doses, also reduced the number of repeated suicide attempts compared with placebo, whereas some anti-depressants, in particular, maprotiline, by contrast, was associated with an increase in such attempts, despite having had the action of anti-[46]. In moderate doses (3 - 40 mg) flupentiksol manifests itself antipsychotic effect, reducing delusions and hallucinations, as well as having an impact on negative symptoms [3]. Given that schizophrenia is peculiar to an increased risk of alcohol abuse, F, including in the form of depot injections is indicated for the treatment of such "mixed" cases [41]. F decanoate (depot injection) was studied as a means of exposure to cocaine addiction [48]. The study authors concluded that F significantly reduces the actual craving for the drug (antikrevingovoe action). Concluding this brief analysis of the literature, it should be noted that the lack of references to the works of Russian psychiatrists and drug treatment due to the fact that the history of clinical use of C and F in Russia has just over one year and only now summed up first, while the few independent studies of these interesting and promising drugs that enhance treatment of mental and substance abuse pathology.