Both drugs showed a high ...

Results in Italy were even more encouraging [31]. Tsipramil (20 mg / day) and flyuvoksamin (150 mg / day) were assigned, respectively, 33 and 25 patients diagnosed with alcohol physiological dependence (by DSM-IV). Study, placebo-controlled lasted 16 weeks. Both drugs showed high efficacy of alcohol: the end of the study about 60% of patients in both groups to refrain from drinking alcohol, which significantly distinguished them from the control group receiving placebo (p = 0.04). Moreover patients against designated citalopram rapidly and significantly reduces craving for alcohol. Although flyuvoksamin also reduced craving for alcohol, it was slower and not as pronounced as when using C. Evaluating the effectiveness of the use of SSRIs as a means of influencing the attraction to alcohol, some authors rightly note that the results of these studies could be more specific in the case if, in The studies took into account the different subtypes of alcoholism [32,33]. Thus, as shown by literature data antidepressant C can be applied not only to treat comorbid depressive disorders, but also as a means antikrevingovoe directly affects the craving for alcohol. Flupentiksola place in the treatment of alcoholism from the second in this review of psychotropic drugs, neuroleptics Flyuanksol (F), which derives thioxanthenes can be used in the treatment of alcohol related mental disorders (depression and schizophrenia) as well as for removal of the manifestations of alcohol withdrawal. The impact of F on the withdrawal symptoms have been clearly demonstrated in a study conducted in Sweden for almost 4 years [34]. Total flupentiksol administered, 225 patients were alcoholics who were in a state of abstinence. O was given orally in drops as a single dose of 80 mg. In 2 - 3 hours showed pronounced sedative effect of the drug, which lasted 2 - 3 days. Patients, especially on the first day, many were asleep or in a state of drowsiness. In addition to the sedative drug has also a pronounced anxiolytic action that was important in such cases. The effectiveness of F on the main withdrawal symptoms in 57% of cases assessed as high, in 31% of cases - as the average. The authors noted "amazing" is a rare development of extrapyramidal symptoms, although 80 mg of the drug for a higher dose. That is, depending on the dosage manifest different clinical effects of F, which is characterized by the breadth of the spectrum of their pharmacological activity [3]. Thus, the F in low doses (3 mg) has a distinct antidepressant [35], protivotrevozhnym [36] and activates [40] effect, reduces the psychosomatic symptoms [44]. O at low doses compared with the treatment of depression with antidepressants like amitriptyline [37], nortriptyline [36] Mianserin [38], flyuvoksamin [47] and showed equal with antidepressant activity.