Usually a day requires 3.2 injections of cholecystokinin. Duration treatment - an average of 4 days (from 2 to 6 days). As a rule, the main manifestations of the opium withdrawal syndrome (fever, joint pain, sweating), cropped by the end of the second day of treatment. However, even for one day, in some cases remained asthenic conditions (fatigue, weakness, fatigue, hung, etc.). Among the side effects arising from it should be noted in rare cases nausea, vomiting, sweating, dizziness, hot flashes, cramps in the stomach that arise during the introduction. However, in most cases, these phenomena are observed after the first injection, and they can be avoided by a slower introduction or reduction of drug concentration in the input solution. As a means to relieve the opium withdrawal syndrome developed a scheme for the combined use of opiate antagonists (naloxone hydrochloride) with tools that remove manifestations of withdrawal caused by the introduction of naloxone, namely alpha-2 adrenergic blocker clonidine. Naloxone accelerates the release of metabolites of opium receptors, which reduces the time knocking up to 5-6 days. It is advisable in the first days of therapy to assign maximum dosage clonidine (0,9-1,2 mg) and minimal - naloxone ( 0.2 mg), and then gradually reduce the dose of the first and second dose increase (up to 1.8 mg / day), so that by the end of treatment the patient received only naloxone hydrochloride. Before the advent of the therapeutic arsenal of drug treatment clonidine for the relief of opiate withdrawal has been widely used pirroksan having alpha-adrenoblokiruyuschee action. To remove the acute effects of withdrawal and the suppression of craving for drugs are appointed by the tablet form of the drug in large doses: 0,03 (2 tablets) 4-5 times per day or 0.045 (3 tablets) 3 times a day . However, assigning pirroksan, please note that it has the ability to lower blood pressure. contraindications to its use are: pronounced atherosclerosis, coronary insufficiency, chronic cardiopulmonary syndrome, stroke, blood diseases, pregnancy. Some authors recommend the use for the relief of opioid withdrawal higher doses of atropine. In patients who abuse drugs sedative sleeping pill group (mainly barbiturates), the dose of the drug reduced gradually to avoid the possibility of development in the structure of withdrawal seizures and psychosis. Or is appointed replacement therapy: 30 mg of phenobarbital for each 100 mg abusing sleeping pills , ie about 1 / 3 dose. After two days of stabilization on the selected dose of conducting its gradual decline until the complete abolition or appointed within 4-5 days paglyuferal - 2 tablets 2-3 times a day. For relief of withdrawal symptoms, developing patients with barbiturate addiction, substance abuse of sedatives (benzodiazepine tranquilizers, antihistamines, etc.), poly, which consists in the systematic use of barbiturates or other sedatives, and good results were obtained when using the drug mildronate.
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