Staphylococcus aureus was ...

However, in light of degradation phenomena persisted in the form of thin "dry" cavity, and the presence of bacterial endocarditis is constantly threatened by recurrent sepsis. On radiographs and CT scan of the chest identified multiple foci of destruction on both sides with a slight perifocal reaction (Fig. 4 and Fig. 5). On the 18 th day of hospital stay was performed X-ray control lungs showed the presence of pleural effusion in the left sinus. Under ultrasound was performed pleural puncture and received 50 ml of hemorrhagic fluid, sowing which revealed no growth of pathogenic microorganisms. The presence of severe intoxication, encephalopathy, hepatosplenomegaly, and bilirubinemia hyperfermentemia required to exclude the activity of chronic hepatitis C. A negative result of PCR, as well as normalization of enzymes and bilirubin levels on the background of the active antibacterial treatment would include the liver-cell failure in this patient to the manifestations of sepsis, not active hepatitis. Combined therapy the patient's condition stabilized, and therefore the decision was made to send the patient to the cardiac clinic. Figure 4. Radiograph of patient L., 22, as shown by our examples, the incidence of infective endocarditis among injecting drug users increases due to the widespread injecting drug use. The most frequently affected tricuspid valve. According to the literature, the process may also involve other valves [3]. At the cantonal hospital in Zurich, was a prospective study of 22 patients with infective endocarditis (mean age 23 years). Follow-up was three years [3]. Tricuspid valve was struck in 13 patients, mitral valve - in four, combined tricuspid, mitral lesion was observed in five patients and aortic valve was struck by one patient. Staphylococcus aureus was the most frequent pathogen (in 15). Potential factors in its pathogenicity, defining the clinical picture of sepsis, the following are enterotoxins: SEA, SEB, SEC, SED and toxic shock syndrome toxin (TSST-1). These substances bind proteins interstitsilnogo matrix: fibronectin kolllagenom type I and II and bone sialoproteinom (BSP). However, these factors are not predominant among patients with infective endocarditis caused by Staphylococcus aureus [2]. BSP prevails in patients with skin lesions, while in patients with endocarditis is most often distinguished strains of microorganisms without producing enterotoxins. In our opinion, based on a particular generation of pathogens, it can be assumed that the clinical manifestations of sepsis associated with a primary focus of infection in the skin (eg abrasions), are by their uniform pattern, while in staphylococcal endocarditis pathogenicity factors or patchy absent.