The most severe form - hepatic ...

To the first group of drugs can be attributed Halothane, Isoniazid, radiopaque funds, derivatives of testosterone, a second group of drugs - oral contraceptives (containing estrogen and progestogen), antibiotics (penicillin group, erythromycin, tetracycline derivatives). Risk factors for drug use, knowingly providing the liver toxicity are the presence of the patient's chronic liver disease, age (older people the rate of exchange of drugs reduced), allergic reactions to certain drugs in the past, heredity (allergic reactions to drugs in the immediate family) diseases, autoimmune nature. Clinical manifestations of drug liver disease are varied and not substantially different from those in other diseases. The most severe form - hepatic coma, which develops immediately after the injection (radiopaque means ftorotanovy anesthesia). There are jaundice, itchy skin, expressed general weakness, fever, abdominal pain, enlarged liver, nausea, vomiting, as well as asymptomatic illness within a few days taking the medication, with subsequent development of signs of severe liver injury. Prevention of drug liver disease - a complex and not solved until the end of the problem . The rapid growth of the number of drugs used in clinical practice are often not thoroughly testing them, changing the immune status of the population, the increase in troop strength of elderly will undoubtedly help to increase the frequency of side effects of drugs. Identify communication liver with taking a drug presents considerable difficulties. Therefore, the wide introduction in practice of liver function tests for any suspicion of the presence of side-effect of the drug. In the absence of liver disease, the change of the liver function test requires careful attention and, if necessary - the drug. In all cases, the signs of liver disease should be considered likely side effect of used drugs, especially when it comes to disease, reminiscent of viral hepatitis in patients of middle and old age. If viral hepatitis can be excluded, then the cause of liver disease are often medications. Reduced frequency of severe adverse reactions is possible only in the study efficacy with a wide participation of people of all age groups and patients with liver disease. The development of toxic liver lesions can provoke a number of chemicals (chlorinated hydrocarbons, chlorinated naphthalene, benzene and its derivatives, etc.), as well as metals and metalloids, which became widespread in industry, agriculture and households. In using them appear different degree change in the structure of liver tissue with the death of liver cells, inflammation in the liver.